Complement C3a and Tachykinins Hyperreponsiveness through Regulation by Syncytial Virus-Associated Airway Th17 Cytokines Are Critical for Respiratory
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Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses.
RATIONALE The factors that control the secretion of epithelial mucins are essential to understanding obstructive airway diseases such as asthma. Although the complement anaphylatoxin C3a and its receptor have been shown to promote many features of allergic lung inflammation, the contribution to mucin expression has not been elucidated. OBJECTIVES To determine if the C3a receptor with its liga...
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Objective(s): Th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. To address this point, the effect of nebulized inhalation of inactivated Mycobacterium phlei on modulation of asthmatic airway inflammation was investigated. Materials and Methods: 24 male BALB/c mice were randomly divided into three groups: control group (Group A), asthma model group (G...
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تاریخ انتشار 2011